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Top‐down particle fabrication: control of size and shape for diagnostic imaging and drug delivery
Author(s) -
Canelas Dorian A.,
Herlihy Kevin P.,
DeSimone Joseph M.
Publication year - 2009
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.40
Subject(s) - nanotechnology , template , drug delivery , materials science , nanoparticle , particle size , replication (statistics) , lithography , particle (ecology) , computer science , medicine , engineering , virology , chemical engineering , biology , ecology , optoelectronics
Abstract This review discusses rational design of particles for use as therapeutic vectors and diagnostic imaging agent carriers. The emerging importance of both particle size and shape is considered, and the adaptation and modification of soft lithography methods to produce nanoparticles are highlighted. To this end, studies utilizing particles made via a process called Particle Replication In Non‐wetting Templates are discussed. In addition, insights gained into therapeutic cargo and imaging agent delivery from related types of polymer‐based carriers are considered. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies