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Drug‐eluting stent coatings
Author(s) -
Puskas Judit E.,
MuñozRobledo Lyn G.,
Hoerr Robert A.,
Foley John,
Schmidt Steven P.,
EvanchoChapman Michelle,
Dong Jinping,
Frethem Chris,
Haugstad Greg
Publication year - 2009
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.38
Subject(s) - isobutylene , materials science , coating , copolymer , drug eluting stent , polymer , stent , thermoplastic elastomer , chemical engineering , nanotechnology , composite material , surgery , medicine , restenosis , engineering
This paper reviews the development of coronary stents from a polymer scientist's view point, and presents the first results of an interdisciplinary team assembled for the development of new stent systems. Poly(styrene‐b‐isobutylene‐b‐styrene) block copolymer (SIBS), a nanostructured thermoplastic elastomer, is used in clinical practice as the drug‐eluting polymeric coating on the Taxus coronary stent (trademark of Boston Scientific Co.). Our group has been developing new architectures comprising of arborescent (dendritic) polyisobutylene cores (D_SIBS), which were shown to be as biocompatible as SIBS. ElectroNanospray (Nanocopoeia Inc. ™ ) was used to coat test coupons and coronary stents with selected D S IBS polymers loaded with dexamethasone, a model drug. The surface topology varied from smooth to nanosized particulate coating. This paper will demonstrate how drug release profiles were influenced by both the molecular weight of the polyisobutylene core and spraying conditions of the polymer‐drug mixture. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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