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Fluorine‐containing nanoemulsions for MRI cell tracking
Author(s) -
Janjic Jelena M.,
Ahrens Eric T.
Publication year - 2009
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.35
Subject(s) - biocompatibility , context (archaeology) , regenerative medicine , in vivo , cell , biomedical engineering , chemistry , nanotechnology , materials science , medicine , biology , biochemistry , paleontology , microbiology and biotechnology , organic chemistry
In this article we review the chemistry and nanoemulsion formulation of perfluorocarbons used for in vivo 19 F MRI cell tracking. In this application, cells of interest are labeled in culture using a perfluorocarbon nanoemulsion. Labeled cells are introduced into a subject and tracked using 19 F MRI or NMR spectroscopy. In the same imaging session, a high‐resolution, conventional ( 1 H) image can be used to place the 19 F‐labeled cells into anatomical context. Perfluorocarbon‐based 19 F cell tracking is a useful technology because of the high specificity for labeled cells, ability to quantify cell accumulations, and biocompatibility. This technology can be widely applied to studies of inflammation, cellular regenerative medicine, and immunotherapy. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging