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Nanoparticle‐based biologic mimetics
Author(s) -
Cliffel David E.,
Turner Brian N.,
Huffman Brian J.
Publication year - 2008
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.20
Subject(s) - nanotechnology , biomolecule , surface plasmon resonance , quartz crystal microbalance , nanomaterials , biosensor , nanoparticle , bioanalysis , materials science , chemistry , organic chemistry , adsorption
Centered on solid chemistry foundations, biology and materials science have reached a crossroad where bottom‐up designs of new biologically important nanomaterials are a reality. The topics discussed here present the interdisciplinary field of creating biological mimics. Specifically, this discussion focuses on mimics that are developed using various types of metal nanoparticles (particularly gold) through facile synthetic methods. These methods conjugate biologically relevant molecules, e.g., small molecules, peptides, proteins, and carbohydrates, in conformationally favorable orientations on the particle surface. These new products provide stable, safe, and effective substitutes for working with potentially hazardous biologicals for applications such as drug targeting, immunological studies, biosensor development, and biocatalysis. Many standard bioanalytical techniques can be used to characterize and validate the efficacy of these new materials, including quartz crystal microbalance (QCM), surface plasmon resonance (SPR), and enzyme‐linked immunosorbent assay (ELISA). Metal nanoparticle–based biomimetics continue to be developed as potential replacements for the native biomolecule in applications of immunoassays and catalysis. Copyright © 2008 John Wiley & Sons, Inc. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology