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Degradable branched polycationic systems for nucleic acid delivery
Author(s) -
Qi Yu,
Xu Chen,
Xu FuJian
Publication year - 2020
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1631
Subject(s) - nucleic acid , transfection , chemistry , nanotechnology , gene delivery , delivery system , biochemistry , materials science , biology , gene , pharmacology
Nowadays, nucleic acid‐based therapy has become a promising way for the treatment of various malignant diseases like cancers. However, the process of nucleic acid delivery is hampered by several extracellular and intracellular obstacles. To overcome these obstacles, many nucleic acid delivery carriers have been developed to achieve improved safety and enhanced gene transfection performance. Among these carriers, degradable branched polycations have attracted much attention due to their good responsive degradability and impressive transfection performances. In this review, we mainly summarized the redox‐ and pH‐responsive degradable branched polycationic systems used for nucleic acid delivery. For responsive degradable branched polycationic systems, the preparation methods were introduced, where amino‐epoxy ring‐opening reaction as a novel step growth approach was mainly presented. The properties of redox‐ and pH‐responsive degradable branched polycationic systems were subsequently introduced and highlighted. We hope this brief review will motivate the delicate design of responsive degradable branched polycationic systems for potential clinical applications. This article is categorized under: Biology‐Inspired Nanomaterials > Nucleic Acid‐Based Structures