Premium
Tailoring nanoparticles based on boron dipyrromethene for cancer imaging and therapy
Author(s) -
Lin Wenhai,
ColombaniGaray Daniel,
Huang Ling,
Duan Chunying,
Han Gang
Publication year - 2020
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1627
Subject(s) - bodipy , nanoparticle , photoacoustic imaging in biomedicine , nanotechnology , fluorescence lifetime imaging microscopy , fluorescence , rational design , materials science , boron , cancer therapy , imaging agent , in vivo , chemistry , cancer , medicine , organic chemistry , optics , physics , microbiology and biotechnology , biology
Boron dipyrromethene (BODIPY), as a traditional fluorescent dye, has drawn increasing attention because of its excellent photophysical properties like adjustable spectra and outstanding photostability. BODIPY dyes could be assembled into nanoparticles for cancer imaging and therapy via rational design. In this review, the bio‐applications of BODIPY‐containing nanoparticles are introduced in detail, such as cellular imaging, near‐infrared fluorescence imaging, computed tomography imaging, photoacoustic imaging, phototherapy, and theranostics. The construction strategies of BODIPY‐containing nanoparticles are emphasized so the review has three sections—self‐assembly of small molecules, chemical conjugation with hydrophilic compounds, and physical encapsulation. This review not only summarizes various and colorific bio‐applications of BODIPY‐containing nanoparticles, but also provides reasonable design methods of BODIPY‐containing nanoparticles for cancer theranostics. This article is categorized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging