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In vivo visualization of macrophage infiltration and activity in inflammation using magnetic resonance imaging
Author(s) -
Beckmann Nicolau,
Cannet Catherine,
Babin Anna Louise,
Blé FrançoisXavier,
Zurbruegg Stefan,
Kneuer Rainer,
Dousset Vincent
Publication year - 2009
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.16
Subject(s) - in vivo , magnetic resonance imaging , medicine , inflammation , infiltration (hvac) , macrophage , multiple sclerosis , rheumatoid arthritis , pathology , preclinical imaging , radiology , immunology , chemistry , biology , in vitro , materials science , biochemistry , microbiology and biotechnology , composite material
Because macrophages play a key role on host defense, visualization of the migration of these cells is of high relevance for both diagnostic purposes and the evaluation of therapeutic interventions. The present article addresses the use of iron oxide and gadolinium‐based particles for the noninvasive in vivo detection of macrophage infiltration into inflamed areas by magnetic resonance imaging (MRI). A general introduction on the functions and general characteristics of macrophages is followed by a discussion of some of the agents and acquisition schemes currently used to track the cells in vivo . Attention is then devoted to preclinical and clinical applications in the following disease areas: atherosclerosis and myocardial infarction, stroke, multiple sclerosis, rheumatoid arthritis, and kidney transplantation Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging