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Critical considerations for targeting colorectal liver metastases with nanotechnology
Author(s) -
Arshad Usman,
Sutton Paul A.,
Ashford Marianne B.,
Treacher Kevin E.,
Liptrott Neill J.,
Rannard Steve P.,
Goldring Christopher E.,
Owen Andrew
Publication year - 2019
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1588
Subject(s) - nanocarriers , nanomedicine , colorectal cancer , medicine , disease , cancer , intensive care medicine , nanotechnology , drug , pharmacology , materials science , nanoparticle
Colorectal cancer remains a significant cause of morbidity and mortality worldwide. Half of all patients develop liver metastases, presenting unique challenges for their treatment. The shortcomings of conventional chemotherapy has encouraged the use of nanomedicines; the application of nanotechnology in the diagnosis and treatment of disease. In spite of technological improvements in nanotechnology, the complexity of biological systems hinders the prospect of nanomedicines being applied in cancer therapy at the present time. This review highlights current biological barriers and discusses aspects of tumor biology together with the physicochemical features of the nanocarrier, that need to be considered in order to develop effective nanotherapeutics for colorectal cancer patients with liver metastases. It becomes clear that incorporating an interdisciplinary approach when developing nanomedicines should assure appropriate disease‐driven design and that this will form a critical step in improving their clinical translation. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease