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Immunoengineering in glioblastoma imaging and therapy
Author(s) -
Zanganeh Steven,
Georgala Petrina,
Corbo Claudia,
Arabi Leila,
Ho Jim Q.,
Javdani Najme,
Sepand Mohammad R.,
Cruickshank Kiara,
Campesato Luis F.,
Weng ChienHuan,
Hemayat Saeed,
Andreou Chrysafis,
Alvim Ricardo,
Hutter Gregor,
Rafat Marjan,
Mahmoudi Morteza
Publication year - 2019
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1575
Subject(s) - medicine , magnetic resonance imaging , positron emission tomography , immunotherapy , drug delivery , glioblastoma , blood–brain barrier , radiation therapy , central nervous system , molecular imaging , neuroscience , immune system , in vivo , nanotechnology , cancer research , radiology , biology , immunology , materials science , microbiology and biotechnology
Patients diagnosed with glioblastoma have poor prognosis. Conventional treatment strategies such as surgery, chemotherapy, and radiation therapy demonstrated limited clinical success and have considerable side effects on healthy tissues. A central challenge in treating brain tumors is the poor permeability of the blood–brain barrier (BBB) to therapeutics. Recently, various methods based on immunotherapy and nanotechnology have demonstrated potential in addressing these obstacles by enabling precise targeting of brain tumors to minimize adverse effects, while increasing targeted drug delivery across the BBB. In addition to treating the tumors, these approaches may be used in conjunction with imaging modalities, such as magnetic resonance imaging and positron emission tomography to enhance the prognosis procedures. This review aims to provide mechanistic understanding of immune system regulation in the central nervous system and the benefits of nanoparticles in the prognosis of brain tumors. This article is characterized under: Diagnostic Tools > in vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Cells at the Nanoscale Nanotechnology Approaches to Biology > Nanoscale Systems in Biology