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Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices
Author(s) -
Chen Maria Yanqing,
Butler Susan S.,
Chen Weitong,
Suh Junghae
Publication year - 2018
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1545
Subject(s) - capsid , synthetic biology , computational biology , biology , virus , virology , bacterial virus , plant virus , genome , nanotechnology , bacteriophage , genetics , materials science , gene , escherichia coli
The fields of physical, chemical, and synthetic virology work in partnership to reprogram viruses as controllable nanodevices. Physical virology provides the fundamental biophysical understanding of how virus capsids assemble, disassemble, display metastability, and assume various configurations. Chemical virology considers the virus capsid as a chemically addressable structure, providing chemical pathways to modify the capsid exterior, interior, and subunit interfaces. Synthetic virology takes an engineering approach, modifying the virus capsid through rational, combinatorial, and bioinformatics‐driven design strategies. Advances in these three subfields of virology aim to develop virus‐based materials and tools that can be applied to solve critical problems in biomedicine and biotechnology, including applications in gene therapy and drug delivery, diagnostics, and immunotherapy. Examples discussed include mammalian viruses, such as adeno‐associated virus (AAV), plant viruses, such as cowpea mosaic virus (CPMV), and bacterial viruses, such as Qβ bacteriophage. Importantly, research efforts in physical, chemical, and synthetic virology have further unraveled the design principles foundational to the form and function of viruses. This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Biology‐Inspired Nanomaterials > Protein and Virus‐Based Structures