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Outer membrane vesicles for vaccination and targeted drug delivery
Author(s) -
Wang Sihan,
Gao Jin,
Wang Zhenjia
Publication year - 2018
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1523
Subject(s) - drug delivery , extracellular vesicles , nanomedicine , targeted drug delivery , drug discovery , biogenesis , vesicle , extracellular vesicle , drug , microvesicles , bacterial outer membrane , biology , microbiology and biotechnology , nanotechnology , bioinformatics , pharmacology , membrane , materials science , biochemistry , microrna , escherichia coli , nanoparticle , gene
Extracellular vesicles (EVs) are cell membrane‐derived compartments that spontaneously secrete from a wide range of cells and tissues. EVs have shown to be the carriers in delivering drugs and small interfering RNA. Among EVs, bacterial outer membrane vesicles (OMVs) recently have gained the interest in vaccine development and targeted drug delivery. In this review, we summarize the current discoveries of OMVs and their functions. In particular, we focus on the biogenesis of OMVs and their functions in bacterial virulence and pathogenesis. Furthermore, we discuss the applications of OMVs in vaccination and targeted drug delivery. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Therapeutic Approaches and Drug Discovery > Emerging Technologies Biology‐Inspired Nanomaterials > Lipid‐Based Structures