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Synthetic plant virology for nanobiotechnology and nanomedicine
Author(s) -
Steele John F. C.,
Peyret Hadrien,
Saunders Keith,
CastellsGraells Roger,
Marsian Johanna,
Meshcheriakova Yulia,
Lomonossoff George P.
Publication year - 2017
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1447
Subject(s) - nanobiotechnology , nanomedicine , nanotechnology , nanomaterials , nanoparticle , plant virus , computational biology , materials science , virus , biology , virology
Nanotechnology is a rapidly expanding field seeking to utilize nano‐scale structures for a wide range of applications. Biologically derived nanostructures, such as viruses and virus‐like particles ( VLPs ), provide excellent platforms for functionalization due to their physical and chemical properties. Plant viruses, and VLPs derived from them, have been used extensively in biotechnology. They have been characterized in detail over several decades and have desirable properties including high yields, robustness, and ease of purification. Through modifications to viral surfaces, either interior or exterior, plant‐virus‐derived nanoparticles have been shown to support a range of functions of potential interest to medicine and nano‐technology. In this review we highlight recent and influential achievements in the use of plant virus particles as vehicles for diverse functions: from delivery of anticancer compounds, to targeted bioimaging, vaccine production to nanowire formation. WIREs Nanomed Nanobiotechnol 2017, 9:e1447. doi: 10.1002/wnan.1447 This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Biology-Inspired Nanomaterials > Protein and Virus-Based Structures