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Multifunctional platinum‐based nanoparticles for biomedical applications
Author(s) -
Cheng Qinqin,
Liu Yangzhong
Publication year - 2016
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1410
Subject(s) - nanocarriers , drug delivery , nanotechnology , platinum , platinum nanoparticles , drug , nanoparticle , drug resistance , nanomedicine , cancer , pharmacology , materials science , medicine , chemistry , biology , biochemistry , microbiology and biotechnology , catalysis
Platinum‐based anticancer drugs play a central role in current cancer therapy. However, their applicability and efficacy are limited by drug resistance and adverse effects. Nanocarrier‐based platinum drug delivery systems are promising alternatives to circumvent the disadvantages of bare platinum drugs. The various properties of nanoparticle chemistry allow for the trend toward multiple functionality. Nanoparticles preferentially accumulate at the tumor site through passive targeting, and the attachment of tumor targeting moieties further enhances their tumor‐specific localization as well as tumor cell uptake. The introduction of stimuli‐responsive groups into drug delivery systems can further achieve spatially and temporally controlled drug release in response to specific stimuli. Combination therapy strategies have been used to promote synergetic efficacy and overcome the resistance of platinum drugs. The tumor‐localized drug delivery strategies exhibit benefits for preventing local tumor recurrence. In addition, the combination of platinum drugs and imaging agents in one unity allows the cancer diagnostics for real‐time monitoring the distribution of drug‐loaded nanoparticles inside the body and tumor. This review discusses recent scientific advances in multifunctional nanoparticle formulations of platinum drugs, and these designs exhibit new potential of multifunctional nanoparticles for delivering platinum‐based anticancer drugs. WIREs Nanomed Nanobiotechnol 2017, 9:e1410. doi: 10.1002/wnan.1410 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease