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What is new in nanoparticle‐based photoacoustic imaging?
Author(s) -
Lemaster Jeanne E.,
Jokerst Jesse V.
Publication year - 2016
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1404
Subject(s) - photoacoustic imaging in biomedicine , nanoparticle , molecular imaging , materials science , nanotechnology , ultrasound imaging , preclinical imaging , ultrasound , contrast (vision) , optical imaging , in vivo , optics , medicine , radiology , physics , microbiology and biotechnology , biology
Photoacoustic imaging combines the high temporal and spatial resolution of ultrasound with the good contrast and spectral tuning of optical imaging. Contrast agents are used in photoacoustic imaging to further increase the contrast and specificity of imaging or to image a specific molecular process, e.g., cell‐surface proteins or small molecule biomarkers. Nanoparticle‐based contrast agents are important tools in photoacoustic imaging because they offer intense and stable signal and can be targeted to specific molecular processes. In this review, we describe some of the most interesting and recent advances in nanoparticle‐based photoacoustic imaging including inorganic nanoparticles, organic/polymeric nanoparticles, nanoparticle coatings, multimodality imaging, as well as emerging topics in the field. WIREs Nanomed Nanobiotechnol 2017, 9:e1404. doi: 10.1002/wnan.1404 This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging