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Engineering of radiolabeled iron oxide nanoparticles for dual‐modality imaging
Author(s) -
Ai Fanrong,
Ferreira Carolina A.,
Chen Feng,
Cai Weibo
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1386
Subject(s) - magnetic resonance imaging , positron emission tomography , iron oxide nanoparticles , single photon emission computed tomography , emission computed tomography , preclinical imaging , molecular imaging , modality (human–computer interaction) , nanoparticle , materials science , nuclear medicine , in vivo , biomedical engineering , nuclear magnetic resonance , nanotechnology , chemistry , medicine , radiology , computer science , physics , artificial intelligence , microbiology and biotechnology , biology
Over the last decade, radiolabeled iron oxide nanoparticles have been developed as promising contrast agents for dual‐modality positron emission tomography/magnetic resonance imaging ( PET / MRI ) or single‐photon emission computed tomography/magnetic resonance imaging ( SPECT / MRI ). The combination of PET (or SPECT ) with MRI can offer synergistic advantages for noninvasive, sensitive, high‐resolution, and quantitative imaging, which is suitable for early detection of various diseases such as cancer. Here, we summarize the recent advances on radiolabeled iron oxide nanoparticles for dual‐modality imaging, through the use of a variety of PET (and SPECT ) isotopes by using both chelator‐based and chelator‐free radiolabeling techniques. WIREs Nanomed Nanobiotechnol 2016, 8:619–630. doi: 10.1002/wnan.1386 This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Nanoscale Systems in Biology