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Virus‐based nanoparticles as platform technologies for modern vaccines
Author(s) -
Lee Karin L.,
Twyman Richard M.,
Fiering Steven,
Steinmetz Nicole F.
Publication year - 2016
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1383
Subject(s) - virus , nanotechnology , virology , function (biology) , antigen , computational biology , biology , immunology , materials science , microbiology and biotechnology
Nanoscale engineering is revolutionizing the development of vaccines and immunotherapies. Viruses have played a key role in this field because they can function as prefabricated nanoscaffolds with unique properties that are easy to modify. Viruses are immunogenic via multiple pathways, and antigens displayed naturally or by engineering on the surface can be used to create vaccines against the cognate virus, other pathogens, specific molecules or cellular targets such as tumors. This review focuses on the development of virus‐based nanoparticle systems as vaccines indicated for the prevention or treatment of infectious diseases, chronic diseases, cancer, and addiction. WIREs Nanomed Nanobiotechnol 2016, 8:554–578. doi: 10.1002/wnan.1383 This article is categorized under: Biology-Inspired Nanomaterials > Protein and Virus-Based Structures