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Use of nanoparticles to deliver immunomodulatory oligonucleotides
Author(s) -
Klinman Dennis M.,
Sato Takashi,
Shimosato Takeshi
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1382
Subject(s) - oligonucleotide , nanoparticle , nanotechnology , computational biology , computer science , chemistry , materials science , biology , dna , biochemistry
Synthetic oligonucleotides ( ODNs ) containing unmethylated ‘ CpG motifs’ stimulate the innate immune system to produce cytokines, chemokines, and polyreactive antibodies. CpG ODNs have shown promise as vaccine adjuvants and for the treatment of infectious diseases and cancer. The immunostimulatory activity of CpG ODNs is inhibited by DNA ‐containing ‘suppressive’ motifs. ODNs expressing suppressive motifs (Sup ODNs ) reduce ongoing immune reactions and show promise in the treatment of autoimmune and inflammatory diseases. This work reviews recent progress in the use of nanoparticles as carriers of CpG and Sup ODNs to target their delivery to the GI tract and lungs. WIREs Nanomed Nanobiotechnol 2016, 8:631–637. doi: 10.1002/wnan.1382 This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Biology-Inspired Nanomaterials > Nucleic Acid-Based Structures Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease