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Viral chemistry: the chemical functionalization of viral architectures to create new technology
Author(s) -
Chen Zhuo,
Li Na,
Li Shaobo,
Dharmarwardana Madushani,
Schlimme Anna,
Gassensmith Jeremiah J
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1379
Subject(s) - nanotechnology , biomolecule , surface modification , template , chemical modification , drug delivery , chemical biology , polymer , click chemistry , materials science , chemistry , combinatorial chemistry , polymer chemistry , organic chemistry , biochemistry
The modification of viruses using chemical conjugation techniques has brought the distant worlds of virology right into the center of nanotechnology. Viruses are naturally resilient biomolecules and this makes them exceptional templates for the creation of higher order polymers and as scaffolds for biological imaging and targeted drug delivery. In this review, we highlight progress in utilizing chemical strategies to interface viruses with synthetic polymers, to create bright bionanoparticles using synthetic fluorescent dyes, and how orthogonal chemical transformations allow for targeted drug delivery. WIREs Nanomed Nanobiotechnol 2016, 8:512–534. doi: 10.1002/wnan.1379 This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Implantable Materials and Surgical Technologies > Nanomaterials and Implants Biology-Inspired Nanomaterials > Protein and Virus-Based Structures