Premium
Nanoparticle dosage—a nontrivial task of utmost importance for quantitative nanosafety research
Author(s) -
Feliu Neus,
Pelaz Beatriz,
Zhang Qian,
del Pino Pablo,
Nyström Andreas,
Parak Wolfgang J.
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1378
Subject(s) - nanomedicine , nanoparticle , nanotechnology , nanomaterials , biochemical engineering , chemistry , materials science , engineering
For a detailed and correct understanding of effects of colloidal nanoparticles exposed to organisms, a correlation of such effects to the physicochemical properties of the nanoparticles is a necessity. Such correlation is complex by the fact that many physicochemical parameters such as size, shape, surface charge, and colloidal stability are interlinked, and nontrivial to experimentally determine. This review aims to give an overview regarding such correlations. Particular focus will be given on the role of determining nanoparticle concentrations, which is the basis for most quantitative toxicity evaluations. A comparison of mass versus particle number concentrations is given, and their respective differences are highlighted. WIREs Nanomed Nanobiotechnol 2016, 8:479–492. doi: 10.1002/wnan.1378 This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials