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NIR fluorescent small molecules for intraoperative imaging
Author(s) -
Owens Eric A.,
Lee Stephanie,
Choi JungMun,
Henary Maged,
Choi Hak Soo
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1337
Subject(s) - biodistribution , optical imaging , contrast (vision) , nanomedicine , fluorescence , image contrast , in vivo , molecular imaging , preclinical imaging , biomedical engineering , materials science , nanotechnology , nuclear medicine , computer science , optics , medicine , nanoparticle , artificial intelligence , physics , microbiology and biotechnology , biology
Recent advances in bioimaging and nanomedicine have permitted the exploitation of molecular optical imaging in image‐guided surgery; however, the parameters mediating optimum performance of contrast agents are not yet precisely determined. To develop ideal contrast agents for image‐guided surgery, we need to consider the following criteria: (1) excitation and emission wavelengths in the near‐infrared ( NIR ) window, (2) optimized optical characteristics for high in vivo performance, (3) overcoming or harnessing biodistribution and clearance, and (4) reducing nonspecific uptake. The design considerations should be focused on optimizing the optical and physicochemical property criteria. Biodistribution and clearance should first be considered because they mediate the fate of a contrast agent in the body such as how long after intravenous injection a contrast agent reaches the peak signal‐to‐background ratio ( SBR ) and how long the signal lasts (retention). WIREs Nanomed Nanobiotechnol 2015, 7:828–838. doi: 10.1002/wnan.1337 This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging