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Dendrimer‐entrapped metal colloids as imaging agents
Author(s) -
Li Du,
Wen Shihui,
Shi Xiangyang
Publication year - 2015
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1331
Subject(s) - dendrimer , materials science , biocompatibility , nanotechnology , colloid , fluorescence lifetime imaging microscopy , colloidal gold , medical imaging , molecular imaging , nanoparticle , biomedical engineering , fluorescence , chemistry , radiology , polymer chemistry , medicine , optics , in vivo , organic chemistry , physics , microbiology and biotechnology , biology , metallurgy
This review reports the recent advances in dendrimer‐entrapped metal colloids as contrast agents for biomedical imaging applications. The versatile dendrimer scaffolds with 3‐dimensional spherical shape, highly branched internal cavity, tunable surface conjugation chemistry, and excellent biocompatibility and nonimmunogenicity afford their uses as templates to create multifunctional dendrimer‐entrapped metal colloids for mono‐ or multi‐ mode molecular imaging applications. In particular, multifunctional dendrimer‐entrapped gold nanoparticles with different surface modifications have been used for fluorescence imaging, targeted tumor computed tomography ( CT ) imaging, enhanced blood pool CT imaging, dual mode CT / MR imaging, and tumor theranostics (combined CT imaging and chemotherapy) will be introduced and discussed in detail. WIREs Nanomed Nanobiotechnol 2015, 7:678–690. doi: 10.1002/wnan.1331 This article is categorized under: Diagnostic Tools > Diagnostic Nanodevices Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Nanotechnology Approaches to Biology > Nanoscale Systems in Biology