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Ionic α‐helical polypeptides toward nonviral gene delivery
Author(s) -
Zhang Rujing,
Song Ziyuan,
Yin Lichen,
Zheng Nan,
Tang Haoyu,
Lu Hua,
Gabrielson Nathan P.,
Lin Yao,
Kim Kyung,
Cheng Jianjun
Publication year - 2014
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1307
Subject(s) - nanotechnology , gene delivery , drug delivery , computational biology , nanomaterials , gene , small interfering rna , rna , chemistry , biology , materials science , genetic enhancement , biochemistry
The advent of polymeric materials has significantly promoted the development and rapid growth of various technologies in biomedical applications, such as tissue engineering and controlled drug and gene delivery. Water‐soluble polypeptides bearing functional side chains and adopting stable secondary structures are a new class of functional polymeric materials of potentially broad applications in medicine and biotechnology. In this article, we summarize our recent effort on the design and synthesis of the water‐soluble α‐helical ionic polypeptides originally developed in our laboratory and highlight their applications in cell membrane penetration and nonviral gene/small interfering RNA ( siRNA ) delivery. WIREs Nanomed Nanobiotechnol 2015, 7:98–110. doi: 10.1002/wnan.1307 This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Biology-Inspired Nanomaterials > Peptide-Based Structures