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Polymer nanoparticles for drug and small silencing RNA delivery to treat cancers of different phenotypes
Author(s) -
Devulapally Rammohan,
Paulmurugan Ramasamy
Publication year - 2013
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1242
Subject(s) - nanocarriers , nanomedicine , gene silencing , drug delivery , drug , nanotechnology , cancer , cancer therapy , medicine , pharmacology , chemistry , nanoparticle , materials science , gene , biochemistry
Advances in nanotechnology have provided powerful and efficient tools in the development of cancer diagnosis and therapy. There are numerous nanocarriers that are currently approved for clinical use in cancer therapy. In recent years, biodegradable polymer nanoparticles have attracted a considerable attention for their ability to function as a possible carrier for target‐specific delivery of various drugs, genes, proteins, peptides, vaccines, and other biomolecules in humans without much toxicity. This review will specifically focus on the recent advances in polymer‐based nanocarriers for various drugs and small silencing RNA 's loading and delivery to treat different types of cancer. WIREs Nanomed Nanobiotechnol 2014, 6:40–60. doi: 10.1002/wnan.1242 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease