Premium
Fluorinated dendrimers as imaging agents for 19 F MRI
Author(s) -
Yu Yihua Bruce
Publication year - 2013
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1239
Subject(s) - dendrimer , magnetic resonance imaging , molecular imaging , nanotechnology , computer science , medicine , nuclear magnetic resonance , chemistry , medical physics , in vivo , materials science , physics , radiology , organic chemistry , microbiology and biotechnology , biology
19 F is the second most sensitive stable nucleus for magnetic resonance imaging ( MRI ). Because there is no endogenous 19 F signal, 19 F MRI is much more suited for quantification and tracking than 1 H MRI . However, 19 F MRI is not in clinical use because in spite of more than three decades of research, there are no approved 19 F imaging agents. New approaches and new methodologies are needed to move the field forward. Water‐soluble fluorinated dendrimers present a promising alternative to conventional perfluorocarbon emulsions. This article outlines recent development of fluorinated dendrimers as 19 F imaging agents. This is not meant to be a comprehensive review of 19 F imaging agents, for which there is an excellent recent review by Knight et al. Rather, the article aims to give an insider's account on research efforts in this exciting and challenging field. WIREs Nanomed Nanobiotechnol 2013, 5:646–661. doi: 10.1002/wnan.1227 This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > In Vivo Nanodiagnostics and Imaging