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Use of nitric oxide nanoparticulate platform for the treatment of skin and soft tissue infections
Author(s) -
Kutner Allison J.,
Friedman Adam J.
Publication year - 2013
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1230
Subject(s) - antimicrobial , nanomedicine , drug delivery , nanotechnology , antibiotic resistance , drug , drug resistance , broad spectrum , medicine , antibiotics , pharmacology , biology , chemistry , materials science , microbiology and biotechnology , nanoparticle , combinatorial chemistry
The incidence of skin and soft tissue infections ( SSTI ) due to multi‐drug resistant pathogens is increasing. The concomitant increase in antibiotic use along with the ease with which organisms develop mechanisms of resistance have together become a medical crisis, underscoring the importance of developing innovative and effective antimicrobial strategies. Nitric oxide (NO) is an endogenously produced molecule with many physiologic functions, including broad spectrum antimicrobial activity and immunomodulatory properties. The risk of resistance to NO is minimized because NO has multiple mechanisms of antimicrobial action. NO 's clinical utility has been limited largely because it is highly reactive and lacks appropriate vehicles for storage and delivery. To harness NO 's antimicrobial potential, a variety exogenous NO delivery platforms have been developed and evaluated, yet limitations preclude their use in the clinical setting. Nanotechnology represents a paradigm through which these limitations can be overcome, allowing for the encapsulation, controlled release, and focused delivery of NO for the treatment of SSTI . WIREs Nanomed Nanobiotechnol 2013. doi: 10.1002/wnan.1230 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Infectious Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology