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Peptide‐mediated cancer targeting of nanoconjugates
Author(s) -
Raha Sumita,
Paunesku Tatjana,
Woloschak Gayle
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.121
Subject(s) - nanomedicine , nanotechnology , avidity , nanoparticle , small molecule , in vivo , peptide , materials science , cancer , surface modification , cancer cell , chemistry , computational biology , biochemistry , medicine , biology , antibody , microbiology and biotechnology , immunology
Targeted use of nanoparticles in vitro , in cells, and in vivo requires nanoparticle surface functionalization. Moieties that can be used for such a purpose include small molecules as well as polymers made of different biological and organic materials. Short amino acid polymers, peptides, can often rival target binding avidity of much larger molecules. At the same time, peptides are smaller than most nanoparticles and thus allow for multiple nanoparticle modifications and creation of pluripotent nanoparticles. Most nanoparticles provide multiple binding sites for different cargo and targeting peptides which can be used for the development of novel approaches for cancer targeting, diagnostics, and therapy. In this review, we will focus on peptides which have been used for the preparation of different nanoparticles designed for cancer research. WIREs Nanomed Nanobiotechnol 2011 3 269–281 DOI: 10.1002/wnan.121 This article is categorized under: Nanotechnology Approaches to Biology > Cells at the Nanoscale Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease