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Recent advances in stealth coating of nanoparticle drug delivery systems
Author(s) -
Amoozgar Zohreh,
Yeo Yoon
Publication year - 2012
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.1157
Subject(s) - pegylation , nanomedicine , polyethylene glycol , nanotechnology , peg ratio , drug delivery , nanoparticle , surface modification , drug , coating , materials science , polymer , chemistry , pharmacology , medicine , organic chemistry , finance , composite material , economics
Modifying surfaces of nanoparticles (NPs) with polyethylene glycol (PEG), the so‐called PEGylation, is the most commonly used method for reducing premature clearance of NPs from the circulation. However, several reports point out that PEGylation may negatively influence the performance of NPs as a drug carrier. Alternative surface modification strategies, including substitute polymers, conditional removal of PEG, and biomimetic surface modification, may provide solutions for the limitations of PEG. WIREs Nanomed Nanobiotechnol 2012, 4:219–233. doi: 10.1002/wnan.1157 This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease