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Imaging of apoptosis in the heart with nanoparticle technology
Author(s) -
Chen Howard H.,
Josephson Lee,
Sosnovik David E.
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.115
Subject(s) - annexin , in vivo , apoptosis , nanomedicine , medicine , molecular imaging , programmed cell death , heart failure , annexin a5 , preclinical imaging , cancer research , biomedical engineering , pathology , nanotechnology , nanoparticle , chemistry , materials science , biology , biochemistry , microbiology and biotechnology
Apoptosis plays an important role in the loss of cardiomyocytes in both ischemic injury and heart failure. Pioneering work with single photon emission computed tomography imaging of 99 Tc‐annexin showed that cell death in the heart could be imaged in vivo . Over the last 5 years a significant amount of experience with annexin‐labeled magnetic nanoparticles, principally AnxCLIO‐Cy5.5, has also been gained. Here, we review the experience with AnxCLIO‐Cy5.5 in the heart and compare this experience to that of earlier studies with 99 Tc‐annexin. The imaging of apoptosis with AnxCLIO‐Cy5.5 provides valuable insights not only into molecular imaging in the heart but, more broadly, into the use of nanoparticle technology for molecular imaging in general. WIREs Nanomed Nanobiotechnol 2011 3 86–99 DOI: 10.1002/wnan.115 This article is categorized under: Diagnostic Tools > In Vitro Nanoparticle-Based Sensing Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease