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Nanoparticles as magnetic resonance imaging contrast agents for vascular and cardiac diseases
Author(s) -
Chen Wei,
Cormode David P.,
Fayad Zahi A.,
Mulder Willem J. M.
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: nanomedicine and nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.175
H-Index - 72
eISSN - 1939-0041
pISSN - 1939-5116
DOI - 10.1002/wnan.114
Subject(s) - magnetic resonance imaging , nanomedicine , molecular imaging , angiogenesis , modality (human–computer interaction) , medicine , cardiac magnetic resonance imaging , nanoparticle , disease , medical imaging , biomedical engineering , in vivo , nanotechnology , pathology , materials science , radiology , computer science , artificial intelligence , biology , microbiology and biotechnology
Abstract Advances in nanoparticle contrast agents for molecular imaging have made magnetic resonance imaging a promising modality for noninvasive visualization and assessment of vascular and cardiac disease processes. This review provides a description of the various nanoparticles exploited for imaging cardiovascular targets. Nanoparticle probes detecting inflammation, apoptosis, extracellular matrix, and angiogenesis may provide tools for assessing the risk of progressive vascular dysfunction and heart failure. The utility of nanoparticles as multimodal probes and/or theranostic agents has also been investigated. Although clinical application of these nanoparticles is largely unexplored, the potential for enhancing disease diagnosis and treatment is considerable. WIREs Nanomed Nanobiotechnol 2011 3 146–161 DOI: 10.1002/wnan.114 This article is categorized under: Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Cardiovascular Disease