Open AccessP2Y receptors in neurogenesis
Author(s) -
Illes Peter,
Messemer Nanette,
Rubini Patrizia
Publication year - 2012
Publication title -
wiley interdisciplinary reviews: membrane transport and signaling
Language(s) - English
Resource type - Journals
eISSN - 2190-4618
pISSN - 2190-460X
DOI - 10.1002/wmts.76
Subject(s) - receptor , p2y receptor , microbiology and biotechnology , neurogenesis , intracellular , purine , nucleotide , blot , phosphorylation , signal transduction , biology , chemistry , biochemistry , purinergic receptor , enzyme , gene
G protein‐coupled P2Y receptors (Rs) regulate the function of embryonic and adult neural precursor cells (NPCs) which have the capacity to regenerate and give rise to cells belonging to all three major linages of the nervous system: neurons, oligodendrocytes and astrocytes. The presence of mRNA and protein for various P2YRs have been demonstrated by RT‐PCR, immunohistochemistry and western‐blotting in NPCs. In agreement with the sensitivity of different subtypes of P2YRs to purine and pyrimidine nucleotides, the ATP‐responsive P2Y 1 R and the ATP/UTP‐responsive P2Y 2 R both released intracellular Ca 2+ from its storage sites in NPCs. Nucleotide‐induced Ca 2+ oscillations have a signaling function in NPC syncitia and appear to be involved in cellular proliferation. Two further NPC functions regulated by P2Y receptors are migration and differentiation, especially through P2Y 1 R‐activation, although P2Y 2 Rs may also participate. WIREs Membr Transp Signal 2013, 2:43–48. doi: 10.1002/wmts.76 For further resources related to this article, please visit the WIREs website .