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Randomized clinical trials
Author(s) -
Zheng Lu,
Zelen Marvin
Publication year - 2009
Publication title -
wiley interdisciplinary reviews: computational statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.693
H-Index - 38
eISSN - 1939-0068
pISSN - 1939-5108
DOI - 10.1002/wics.63
Subject(s) - randomization , clinical trial , restricted randomization , inference , randomized controlled trial , causal inference , cluster randomised controlled trial , computer science , medicine , medical physics , statistics , artificial intelligence , mathematics
Randomization is widely recognized as a fundamental principle in the design of Phase III clinical trials. It is a way to minimize conscious and unconscious bias among patients and physicians with regard to treatment assignment and treatment acceptability. This paper outlines the advantages and disadvantages of randomization in clinical trials with discussions in permuted blocks, stratified randomization, cluster randomization, and the role of randomization as a basis for inference. Copyright © 2009 John Wiley & Sons, Inc. This article is categorized under: Applications of Computational Statistics > Clinical Trials