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Sequential diagnostic trial designs
Author(s) -
Dong Ting,
Tang Liansheng
Publication year - 2010
Publication title -
wiley interdisciplinary reviews: computational statistics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.693
H-Index - 38
eISSN - 1939-0068
pISSN - 1939-5108
DOI - 10.1002/wics.136
Subject(s) - sample size determination , clinical trial , clinical study design , research design , medical physics , sample (material) , medicine , computer science , statistics , mathematics , chemistry , chromatography
Group sequential design (GSD) as an alternative of the fixed sample design addresses both cost and ethical concerns in diagnostic trials. In this article, we review GSD methods for comparing the diagnostic accuracy of markers in diagnostic trials. We also review sample size calculation methods in such trials. WIREs Comp Stat 2011 3 79–83 DOI: 10.1002/wics.136 This article is categorized under: Applications of Computational Statistics > Clinical Trials