Cognitive aspects of Fragile X syndrome | Zendy

Huddleston Lillie B. | Zendy; Visootsak Jeannie | Zendy; Sherman Stephanie L. | Zendy

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Cognitive aspects of Fragile X syndrome

Author(s) -

Huddleston Lillie B.,

Visootsak Jeannie,

Sherman Stephanie L.

Publication year - 2014

Publication title -

wiley interdisciplinary reviews: cognitive science

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.526

H-Index - 49

eISSN - 1939-5086

pISSN - 1939-5078

DOI - 10.1002/wcs.1296

Subject(s) - fragile x syndrome , neurocognitive , intellectual disability , borderline intellectual functioning , cognition , neuropsychology , psychology , intelligence quotient , fmr1 , cognitive psychology , developmental psychology , psychiatry , fragile x , genetics , biology , gene

Fragile X syndrome ( FXS ) is the leading inherited cause of intellectual disability. It is primarily caused by the expansion of a CGG trinucleodide repeat located in the 5′ untranslated region of the X‐linked FMR1 gene. Individuals with FXS present with variable intellectual quotients ( IQs ) ranging from the average to the severe intellectual disability level. A range of neurocognitive strengths and challenges are observed in individuals with FXS . This article provides an overview of our current understanding related to cognition and FXS . Cognitive functioning levels, profiles, and IQ trajectories are discussed. Limitations of existing neuropsychological measures are described. WIREs Cogn Sci 2014, 5:501‐508. doi: 10.1002/wcs.1296 This article is categorized under: Neuroscience > Cognition

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