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Cognitive aspects of Fragile X syndrome
Author(s) -
Huddleston Lillie B.,
Visootsak Jeannie,
Sherman Stephanie L.
Publication year - 2014
Publication title -
wiley interdisciplinary reviews: cognitive science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.526
H-Index - 49
eISSN - 1939-5086
pISSN - 1939-5078
DOI - 10.1002/wcs.1296
Subject(s) - fragile x syndrome , neurocognitive , intellectual disability , borderline intellectual functioning , cognition , neuropsychology , psychology , intelligence quotient , fmr1 , cognitive psychology , developmental psychology , psychiatry , fragile x , genetics , biology , gene
Fragile X syndrome ( FXS ) is the leading inherited cause of intellectual disability. It is primarily caused by the expansion of a CGG trinucleodide repeat located in the 5′ untranslated region of the X‐linked FMR1 gene. Individuals with FXS present with variable intellectual quotients ( IQs ) ranging from the average to the severe intellectual disability level. A range of neurocognitive strengths and challenges are observed in individuals with FXS . This article provides an overview of our current understanding related to cognition and FXS . Cognitive functioning levels, profiles, and IQ trajectories are discussed. Limitations of existing neuropsychological measures are described. WIREs Cogn Sci 2014, 5:501‐508. doi: 10.1002/wcs.1296 This article is categorized under: Neuroscience > Cognition