Open AccessEffect of flaxseed oil on biochemical parameters, hormonal indexes and stereological changes in ovariectomized rats
Author(s) -
Tanideh Romina,
Delavari Shirin,
Farshad Omid,
Irajie Cambyz,
Javad Yavari Barhaghtalab Mohammad,
Koohpeyma Farhad,
KoohiHosseinabadi Omid,
Jamshidzadeh Akram,
Tanideh Nader,
Iraji Aida
Publication year - 2021
Publication title -
veterinary medicine and science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 11
ISSN - 2053-1095
DOI - 10.1002/vms3.372
Subject(s) - ovariectomized rat , phytoestrogens , endocrinology , medicine , alkaline phosphatase , hormone , chemistry , estrogen , biochemistry , enzyme
The ovariectomized rat is a widely used preclinical model for studying postmenopausal and its complications. In this study, the therapeutic effect of flaxseed oil on the ovariectomized adult rats was investigated. Our results showed that biochemical parameters including calcium, oestrogen and progesterone levels increase 8 weeks after ovariectomy in rats. Also, the amount of alkaline phosphatase decreased significantly after 8 weeks compared with the OVX rat. The healing potential of flaxseed oil was proven by successfully recovering the affected tissue and preventing the unpleasant symptoms of ovariectomized rats. The biological effects of flaxseed oil may be due to high amounts of fatty acids, phytoestrogens and an array of antioxidants. The results suggest that flaxseed oil can mimic the action of oestrogen and can be a potential treatment for hormone replacement therapy (HRT).