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Ichthyoses represent a heterogeneous group of hereditary cornification disorders characterized by generalized scaling of the skin. An autosomal recessive congenital ichthyosis ( ARCI ) has been described in American Bulldogs and is caused by a variant in the   NIPAL 4  gene encoding for the  ICHTHYIN  protein. So far, this variant has not been described in other breeds. A 1.5‐year‐old female pedigreed American Bully was referred for generalized scaling and bad coat quality since adoption at 8 weeks of age. Clinical examination, cytological and histopathological examination, and  DNA  testing were performed. Clinical examination revealed a generalized scaling; cytological evaluation using impression with acetate tapes showed a secondary  Malassezia  dermatitis. Histopathological examination revealed a moderate to marked, diffuse, compact orthokeratotic hyperkeratosis with the formation of large scales. Few  Malassezia  were observed in the  stratum corneum  associated with minimal mixed perivascular inflammation and moderate epidermal hyperplasia.  DNA  testing of the dog revealed that he carries two defective alleles of the   NIPAL 4  gene previously described in the American Bulldog. We performed a commercially available breed detection test which, although not specifically testing for “American Bully” signatures, revealed a high probability of American Bulldog  DNA  signature within the past three generations. Topical treatment using a combination of keratolytic and keratomodulator shampoo, emollient and moisturizers spray and antimicrobial wipes achieved a marked clinical improvement after only 1 month. Continuous topical treatment was necessary to maintain clinical improvement. To the authors’ knowledge, this is the first description of the deleterious   NIPAL 4  variant in an American Bully as well as the first description of clinical management and follow‐up of  ARCI  in this breed.

NIPAL4 deletion identified in an American Bully with autosomal recessive congenital ichthyosis and response to topical therapy