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Synthesis and Reactions of 1‐cyclopropyl‐1,3‐bis(trimethylsilyloxy)‐1,3‐buatdiene
Author(s) -
Rahn Thomas,
Langer Peter
Publication year - 2021
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.202000125
Subject(s) - silyl enol ether , regioselectivity , silylation , enol , chemistry , enol ether , oxalyl chloride , ether , medicinal chemistry , silyl ether , chloride , phenols , organic chemistry , catalysis
A cyclopropyl‐substituted 1,3‐bis(silyl enol ether) was prepared in two steps and subsequently employed in the cyclization with oxalyl chloride to give a cyclopropyl‐carbonyl substituted γ‐alkylidenebutenolide. The cyclization of the 1,3‐bis(silyl enol ether) with 1,3‐dielectrophiles afforded cyclopropyl‐carbonyl substituted phenols. The reactions proceeded with very good regioselectivity.
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