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Anti‐inflammatory metabolites from a marine sponge‐associated fungus Aspergillus sp. IMBC‐FP2 .05
Author(s) -
Quang Tran Hong,
Vien Le Thi,
Anh Le Ngoc,
Ngan Nguyen Thi Thanh,
Hanh Tran Thi Hong,
Cuong Nguyen Xuan,
Nam Nguyen Hoai,
Van Minh Chau
Publication year - 2021
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.202000099
Subject(s) - sponge , fungus , aspergillus , microbiology and biotechnology , chemistry , anti inflammatory , biology , pharmacology , botany
Chemical investigation of the marine sponge‐derived fungal strain Aspergillus sp. IMBC‐FP2.05 resulted in isolation of five compounds, including JBIR‐74 ( 1 ), homogentisic acid ( 2 ), methyl (2,5‐dihydroxyphenyl)acetate ( 3 ), 3‐chloro‐2,5‐dihydroxybenzyl alcohol ( 4 ), and p ‐hydroxybenzaldehyde ( 5 ). Their chemical structures were identified by comprehensive analyses of the 1D and 2D NMR and mass spectra in comparison with the previously reported data. Furthermore, nitric oxide (NO) inhibitory effects of the isolated compounds in LPS‐stimulated RAW264.7 cells were also reported.