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A New Approach for the Synthesis of Sotolon in Racemic and Enantioenriched Forms
Author(s) -
Trang Bui Thuy,
Thuong Cao Hai,
Thao Pham Xuan,
Mac Dinh Hung,
Grée Rene
Publication year - 2021
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.202000095
Subject(s) - enantioselective synthesis , chemistry , stereochemistry , organic chemistry , catalysis
Sotolon (3‐hydroxy‐4,5‐dimethyl‐2(5H)‐furanone) has been synthezised both in racemic and enantioenriched forms by a short sequence involving intramolecular tandem isomerization‐aldolisation and tandem izomerization/Mannich reactions as key steps. Optically active Sotolon has been obtained by using ( S )‐ N ‐ tert ‐butane sulfinimine as a chiral starting material.
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