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Five phenolic compounds from Marchantia polymorpha L. and their in vitro antibacterial, antioxidant and cytotoxic activities
Author(s) -
Son Nguyen Cong Thai,
Tan Tran Quoc,
Lien Do Thi My,
Huong Nguyen Thi My,
Tuyen Pham Nguyen Kim,
Phung Nguyen Kim Phi,
Phuong Quach Ngo Diem,
Thu Nguyen Thi Hoai
Publication year - 2020
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.202000088
Subject(s) - antioxidant , marchantia polymorpha , in vitro , cytotoxic t cell , chemistry , traditional medicine , biochemistry , medicine , gene
Lunularin (1) , marchantin A (2) , isoriccardin C (3) , luteolin (4) and apigenin (5) were isolated from the ethyl acetate extract of Marchantia polymorpha collected at Lam Dong province, Vietnam. The chemical structures of these compounds were elucidated by HR‐MS and NMR spectroscopic analysis as well as compared with data in the literature. The evaluation of the cytotoxic activity against MCF‐7, Hep G2, NCI‐H460, and HeLa cancer cell lines of the ethyl acetate extract and compounds (1) and (3) showed that (1) was potent against MCF‐7 cancer cell with the IC 50 value of 4.59±0.38 μg/mL. The evaluation of DPPH radical scavenging activity displayed strong activities of the ethyl acetate extract, compounds (1) and (3) with SC 50 of 12.75±13.27, 3.99±0.47 and 12.81±0.43 μg/mL, respectively, while SC 50 of the positive control Trolox was 7.34±0.87 μg/mL. The antibacterial evaluation on the ethyl acetate extract and two compounds (2) and (3) against Staphylococcus epidermidis showed that (3) possessed remarkably antibacterial activity with the inhibition zone of 12.67 mm at a concentration of 50 μg/well.