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Development of Green protocols for the synthesis of 1 H ‐benzo[d]imidazolo aryl amide derivatives and evaluation of their biological activity
Author(s) -
Laxminarayana E.,
Srinivasa Reddy B.,
Venkata Ramana Reddy Ch.
Publication year - 2020
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.202000079
Subject(s) - aryl , amide , chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl
Benzimidazole scaffold containing chemical derivatives show superior biological activity. In view of this, we synthesized a combination of benzimidazole and aryl amides. The target compounds ( 6a ‐ j ) were synthesized using ethyl 3‐iodobenzoate and benzimidazole as starting materials under microwave conditions. The synthesized compounds were screened against gram (+ve) and gram (‐ve) bacteria as well as for their anti‐oxidant activity. Compound 6a was proved to be most active in inhibiting the DPPH free radical.