Premium
Attenuated total reflection‐Fourier transform infrared spectroscopy ( ATR‐FTIR ) for quantification of piroxicam in tablet dosage from as a green analytical method
Author(s) -
Thang Nguyen Quoc,
Tho Nguyen Thi Mai,
Nga Ho Ngoc,
Phuong Nguyen Thi Kim
Publication year - 2020
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.202000049
Subject(s) - attenuated total reflection , fourier transform infrared spectroscopy , piroxicam , fourier transform , materials science , chemistry , analytical chemistry (journal) , spectroscopy , infrared , chromatography , chemical engineering , optics , medicine , mathematics , physics , mathematical analysis , alternative medicine , pathology , quantum mechanics , engineering
A simple, rapid, precise, accurate, reproducible, economic and eco‐friendly analytical method for the quantification of piroxicam in tablet dosage form, using attenuated total reflectance Fourier transform infrared spectroscopy (ATR‐FTIR), has been developed. The measurements were based on the ATR technique, wherein there is no sample preparation, except for pulverizing the tablet, thereby eliminating the use of toxic chemicals or solvents. The calibration curve of piroxicam was obtained by performing a linear regression analysis, using data from the direct ATR‐FTIR measurement of percentage transmittance (%T), corresponding to the secondary peak at 1526.38 cm ‐1 in the concentration (C) range of 25.18‐93.63 mg/g. The linear regression equation obtained from the present data was represented by %T = ‐0.2178 C + 99.208 and was associated with a coefficient of determination (r 2 ) of 0.998. The proposed method was validated for piroxicam in tablet form. The relative standard deviation percentage (%RSD) was found to be less than five, with a recovery percentage in the range of 96.0‐99.3 %.