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Flavonoids and Alkaloids from Marine‐Derived Actinomycete Streptomyces sp. C011
Author(s) -
Hoa Tran Thi Thanh,
Van Nam Vu,
Huong Doan Thi Mai,
Dao Phi Thi,
Phuong Nguyen Nam,
Minh Le Thi Hong,
Quyen Vu Thi,
Anh Nguyen Mai,
Murphy Brian T.,
Ly Ho Thi Minh,
Van Cuong Pham
Publication year - 2020
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.202000046
Subject(s) - streptomyces , chemistry , microbiology and biotechnology , food science , biology , bacteria , genetics
Five secondary metabolites including three flavonoids, 6‐lavandulyl‐5,7,2′,4′‐tetrahydroxyflavanone ( 1 ), 5′‐lavandulyl‐2′‐methoxy‐2,4,4′,6′‐tetrahydroxychalcone ( 2 ), 6‐lavandulyl‐7‐methoxy‐5,2′,4′‐trihydroxyflavanone ( 3 ), and two alkaloids, tryptoline ( 4 ), and norharman ( 5 ) were isolated from the culture broth of Streptomyces sp. C011. Their structures were determined by spectral data analysis, including MS, 2D NMR, and CD spectrum. All the separated compounds were evaluated for their antimicrobial activities. Compounds 1 , 2 , 3 and 5 exhibited antimicrobial activity.