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Evaluation on antimicrobial potential of dipterocarpol and dammarenolic acid derivatives from Dipterocarpus alatus
Author(s) -
Smirnova Irina E.,
Thao Tran Thi Phuong
Publication year - 2020
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.202000038
Subject(s) - antimicrobial , cryptococcus neoformans , chemistry , amide , antifungal , carbon 13 nmr , minimum inhibitory concentration , reductive amination , stereochemistry , in vitro , organic chemistry , biochemistry , microbiology and biotechnology , biology , catalysis
Derivatives of natural dipterocarpol, dammarenolic acid and semisynthetic hollongdione were modified by the Beckman rearrangement 2 type, amination and Willgerodt ‐ Kindler reactions. The structures of new compounds were confirmed by MS, 1 H‐NMR and 13 C‐NMR spectroscopic analysis. A ntibacterial and antifungal activities of the compounds were estimated at the University of Queensland (Australia) . The result of the in vitro antimicrobial inhibitory activity revealed N ‐methylpiperazinyl amide of dammarenolic acid a new lead compound with significant antifungal activity against Cryptococcus neoformans var. Grubii (MICs ≤ 0.25 μg/ml) being about ≈ 30 fold more active than the reference compound of fluconazole.
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