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Molecular iodine‐catalyzed N ‐benzylation of anilines substituted by electron withdrawing groups
Author(s) -
Tram Nguyen Thi Thu,
Dat Tong Ho,
Phong Truong Hoai,
Dam Nguyen Phuc,
Tuan Nguyen Trong
Publication year - 2019
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201960017
Subject(s) - aniline , iodine , catalysis , aryl , chemistry , alkylation , polar effect , medicinal chemistry , organic chemistry , alkyl
Fourteen derivatives of N ‐alkylated anilines bearing electron withdrawing group from available aryl alcohols and the parent N ‐unsubstituted aniline using iodine‐catalyst were synthesized throughout a convenient and green protocol, in which three derivatives were previously unreported compounds. The structures of these compounds were elucidated by HRMS, NMR spectral data and in comparison with the literature.