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Effects of processing conditions on properties and morphology of chitosan/lovastatin particles
Author(s) -
Thang Dam Xuan,
Chinh Nguyen Thuy,
Ngoc Dinh Hong,
Tung Nguyen Quang,
Hoang Thai
Publication year - 2019
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201960014
Subject(s) - lovastatin , chitosan , fourier transform infrared spectroscopy , morphology (biology) , chemical engineering , dichloromethane , materials science , dissolution , polyethylene glycol , chemistry , chromatography , solvent , organic chemistry , biochemistry , cholesterol , biology , engineering , genetics
This paper presents the effect of processing conditions on properties and morphology of chitosan particles loading lovastatin as a model drug. The processing conditions were investigated here including solvents for dissolution of drug, emulsifier content and temperature of drying process. Two solvents chosen to dissolve lovastatin were ethanol and dichloromethane. Polyethylene oxide used as an emulsifier with different contents for preparation of chitosan/lovastatin particles. Two methods for evaporation of water in the samples were freeze‐drying and natural air drying in convection oven. The characteristic properties and morphology of chitosan/lovastatin particles were observed, determined and evaluated by Fourier transform infrared spectra, size distribution, and scanning emission microscopy images. From the above data and images, we can find the most suitable condition for the preparation of chitosan/lovastatin particles.