Premium
Cycloartane triterpenoids and biological activities from the propolis of the stingless bee Lisotrigona furva
Author(s) -
Thanh Le Nguyen,
Thoa Ha Thi,
Oanh Nguyen Thi Tu,
Giap Tran Huu,
Quyen Vu Thi,
Ha Nguyen Thi Thu,
Phuong Diep Thi Lan,
Lien Nguyen Thi Phuong,
Hang Nguyen Thi Minh
Publication year - 2021
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201900143
Subject(s) - propolis , stingless bee , triterpenoid , traditional medicine , chemistry , business , biology , medicine , botany , hymenoptera , apidae
Chromatographic separation of ethyl acetate extract of the stingless bee Lisotrigona furva propolis, that collected in Khanh Hoa province, led to isolation of five cycloartane‐type triterpenes including cycloartenone ( 1 ), cycloartenol ( 2 ), (24 E )‐3 β ‐hydroxycycloart‐24‐en‐26‐al ( 3 ), mangiferonic acid ( 4 ) and mangiferolic acid ( 5 ). Mango plant ( Mangifera indica ) was suggested to be a resin source of the propolis. The propolis EtOH extract showed good antimicrobial activity on Gram (+) strain E. feacalis and fungus C. albicans . Among the isolated compounds, compound 3 displayed selective activity against three Gram (+) strains and C. albicans over Gram (‐) strains with all MIC values of 64 μg/mL. However, the propolis EtOH extract was not active against LU‐1 and MCF‐7 cancer cell lines. Only compound 5 exhibited moderate activity on LU‐1 cancer cell line with IC 50 of 13.33 μg/mL.