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Bioactive compounds from marine Streptomyces sp.: Structure identification and biological activities
Author(s) -
AbdEllatif Aya E. S.,
AbdelRazek Ahmed S.,
Hamed Abdelaaty,
Soltan Maha M,
Soliman Hesham S. M.,
Shaaban Mohamed
Publication year - 2019
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201900108
Subject(s) - antimicrobial , ferulic acid , uracil , chemistry , uridine , streptomyces , antioxidant , stereochemistry , biochemistry , organic chemistry , bacteria , biology , rna , gene , dna , genetics
The marine Iotrochoto purpurea derived Streptomyces sp. IOPU produced ten diverse bioactive compounds: hexahydro‐menaquinone MK‐9 ( 1 ), borrelidin ( 2 ), ferulic acid ( 3 ), N‐acetylanthranilic acid ( 4 ), uracil ( 5 ), uridine ( 6 ) , thymidine ( 7 ), sitosteryl‐3 β ‐D‐glucoside, linoleic acid and methyl linoleate. Structures of the obtained compounds were assigned by NMR and mass spectrometric means. The cytotoxic and antimicrobial activities of the extract were visualized against KB‐3‐1 and KB‐V1 cell lines, and a set of microorganisms. Borrelidin ( 2 ), was the potentially active against the colorectal Caco‐2 and breast MCF‐7 subtypes, with IC 50 5.3 μM and < 3.1 μM, respectively. The obtained compounds were investigated as antioxidant and antimicrobial agents.