Flavonoids from the stem barks of  Swintonia griffithii  Kurz (Anacadiaceae) and their tyrosinase inhibitory activities | Zendy

Phu Dang Hoang | Zendy; Tho Le Huu | Zendy; Truong Do Van Nhat | Zendy; Hai Nguyen Xuan | Zendy; Mai Nguyen Thi Thanh | Zendy; Nhan Nguyen Trung | Zendy

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Flavonoids from the stem barks of Swintonia griffithii Kurz (Anacadiaceae) and their tyrosinase inhibitory activities

Author(s) -

Phu Dang Hoang,

Tho Le Huu,

Truong Do Van Nhat,

Hai Nguyen Xuan,

Mai Nguyen Thi Thanh,

Nhan Nguyen Trung

Publication year - 2019

Publication title -

vietnam journal of chemistry

Language(s) - English

Resource type - Journals

eISSN - 2572-8288

pISSN - 0866-7144

DOI - 10.1002/vjch.201900080

Subject(s) - taxifolin , eriodictyol , tyrosinase , chemistry , traditional medicine , inhibitory postsynaptic potential , flavanone , naringenin , biochemistry , flavonoid , antioxidant , biology , medicine , enzyme , neuroscience

From the stem barks of Swintonia griffithii , six flavonoids: (–)‐naringenin ( 1 ), (–)‐eriodictyol ( 2 ), (+)‐taxifolin ( 3 ), (–)‐butin ( 4 ), (–)‐fustin ( 5 ), and 3′,4′,7‐trihydroxyflavone ( 6 ) were isolated. Their structures were determined based on the spectroscopic interpretation and compared with those of reported data. In the tyrosinase inhibitory activity test, (+)‐taxifolin ( 3 ) and 3′,4′,7‐trihydroxyflavone ( 6 ) exhibited potent effect with the IC 50 values of 20.9 and 56.7 μ M, respectively.

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