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Flavonoids from the stem barks of Swintonia griffithii Kurz (Anacadiaceae) and their tyrosinase inhibitory activities
Author(s) -
Phu Dang Hoang,
Tho Le Huu,
Truong Do Van Nhat,
Hai Nguyen Xuan,
Mai Nguyen Thi Thanh,
Nhan Nguyen Trung
Publication year - 2019
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201900080
Subject(s) - tyrosinase , traditional medicine , chemistry , inhibitory postsynaptic potential , botany , biochemistry , biology , medicine , enzyme , neuroscience
From the stem barks of Swintonia griffithii , six flavonoids: (–)‐naringenin ( 1 ), (–)‐eriodictyol ( 2 ), (+)‐taxifolin ( 3 ), (–)‐butin ( 4 ), (–)‐fustin ( 5 ), and 3′,4′,7‐trihydroxyflavone ( 6 ) were isolated. Their structures were determined based on the spectroscopic interpretation and compared with those of reported data. In the tyrosinase inhibitory activity test, (+)‐taxifolin ( 3 ) and 3′,4′,7‐trihydroxyflavone ( 6 ) exhibited potent effect with the IC 50 values of 20.9 and 56.7 μ M, respectively.