Premium
Lupan‐type triterpenoids from the stems of Salacia chinensis L. (Celastraceae) and their α ‐glucosidase inhibitory activities
Author(s) -
Truc Duong Thi Thanh,
Vy Cao Thi Ha,
Phu Dang Hoang,
Hoang Nguyen Minh,
Nhan Nguyen Trung
Publication year - 2019
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201900079
Subject(s) - celastraceae , triterpenoid , traditional medicine , chemistry , stereochemistry , medicine
Six lupan‐type triterpenoids: 29‐norlupan‐3,20‐dione ( 1 ), 3 β ‐hydroxy‐29‐norlupan‐20‐one ( 2 ), betulonic acid ( 3 ), salacianol ( 4 ), 30‐hydroxylup‐20(29)‐en‐3‐one ( 5 ), and lup‐20(29)‐ene‐3 β ,30‐diol ( 6 ) have been isolated from the CHCl 3 ‐soluble fraction of the stem of Salacia chinensis L. (Celastraceae). Their chemical structures were elucidated based on the NMR spectroscopic analysis and comparison with the literatures. Compounds ( 5 ) and ( 6 ) showed very weak α ‐glucosidase inhibitory activity with the IC 50 values of 211.5 and 246.8 μ M, respectively.