Premium
Antiproliferative activity of isolated compounds from Pinus dalatensis and Pinus krempfii on acute myeloid Leukemia cells
Author(s) -
Sa Nguyen Hoang,
Tam Nguyen Thanh,
Quan Tran Duc,
Anh Nguyen Thi Hoang,
Linh Nguyen Thi Thuy,
Nhung Le Thi Hong,
Adorisio Sabrina,
Delfino Domenico V,
Van Sung Tran,
Thuy Trinh Thi
Publication year - 2019
Publication title -
vietnam journal of chemistry
Language(s) - English
Resource type - Journals
eISSN - 2572-8288
pISSN - 0866-7144
DOI - 10.1002/vjch.201900062
Subject(s) - chrysin , myeloid leukemia , pinus <genus> , chemistry , cell cycle progression , leukemia , pharmacology , biological activity , traditional medicine , cell cycle , cell , botany , biology , biochemistry , medicine , cancer research , immunology , in vitro , flavonoid , antioxidant
Our previous chemical constituent study of Pinus dalatensis and Pinus krempfii had identified six compounds 1‐6 . The continuing investigation of biological activity of the conifer species led to discovery of the antiproliferative activity of all isolated compounds 1‐6 on acute myeloid leukemia cells as shown by the effects on cell cycle progression. Remarkably, compound 3 (chrysin) exibited potent bioactivity at the concentration of 10 μg/mL.